Denosumab and invasive cervical root resorption: a case report.

Area of Science:

• Oncology
• Dentistry
• Pharmacology

Background:

• Metastatic breast cancer treatment often involves long-term therapies.
• Denosumab is a common treatment option for bone metastases.
• Improved cancer survival rates increase the number of patients on long-term medications.

Observation:

• A case report details an adverse dental side effect in a patient undergoing long-term denosumab therapy.
• The patient, with metastatic breast cancer, developed extensive invasive cervical root resorption affecting most teeth.
• No other contributing risk factors for the dental condition were identified.

Findings:

• Long-term denosumab use is associated with invasive cervical root resorption.
• This dental adverse effect can be severe and widespread.
• The exact mechanism linking denosumab to root resorption requires further investigation.

Implications:

• Dental practitioners must be aware of potential denosumab-induced dental complications.
• Comprehensive dental examinations, including radiography, are essential for patients on long-term denosumab.
• Early identification of invasive cervical root resorption can guide dental management in cancer survivors.