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Evaluating systemic immune-inflammation index in patients with implantable cardioverter defibrillator for heart

Mert İlker Hayıroğlu1, Tufan Çınar2, Göksel Çinier1

  • 1Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Pacing and Clinical Electrophysiology : PACE
|January 3, 2022
PubMed

Insights

The systemic immune-inflammation index (SII) can predict long-term mortality and appropriate intracardiac defibrillator (ICD) therapy in heart failure with reduced ejection fraction (HFrEF) patients. Higher SII levels indicate increased risk for these adverse outcomes.

Area of Science:

  • Cardiology
  • Immunology
  • Biomarkers

Background:

  • Pro-inflammatory pathways are significant in managing patients with intracardiac defibrillators (ICDs) for heart failure with reduced ejection fraction (HFrEF).
  • The systemic immune-inflammation index (SII), a novel marker, shows prognostic potential in cardiovascular diseases.
  • Evaluating SII's association with long-term outcomes in HFrEF patients with ICDs is crucial.

Purpose of the Study:

  • To assess the prognostic value of the systemic immune-inflammation index (SII) in patients with HFrEF receiving ICD therapy.
  • To determine the association between SII and long-term mortality.
  • To evaluate the relationship between SII and appropriate ICD therapy over a 10-year follow-up.

Main Methods:

  • Retrospective analysis of 1011 patients with ICD for HFrEF.
  • Calculation of SII using the neutrophil-to-lymphocyte ratio multiplied by total platelet count.
  • Stratification of patients based on an optimal SII cut-off value for predicting mortality and appropriate ICD therapy.

Main Results:

  • Patients with a higher SII (≥1119) exhibited significantly increased rates of long-term mortality and appropriate ICD therapy.
  • Adjusted analysis revealed a 5.1-fold higher risk of long-term mortality (95% CI: 2.9-8.1) in patients with higher SII.
  • A 2.0-fold higher risk of long-term appropriate ICD therapy (95% CI: 1.4-3.0) was observed in patients with higher SII.

Conclusions:

  • The systemic immune-inflammation index (SII) may serve as an independent predictive marker.
  • SII is associated with both long-term mortality and appropriate ICD therapy in HFrEF patients.
  • This index offers valuable prognostic information for managing HFrEF patients with ICDs.
Abstract

Keywords:
intracardiac defibrillatorlymphocyteneutrophilplateletsystemic immune-inflammation index

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