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Updated: Oct 8, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
In adults aged 75 to 76 y, systematic AF screening reduced morbidity and mortality at 6 y
Mohammed Yousufuddin1, Arshad Jahangir2
1Mayo Clinic Health System, Austin, Minnesota, USA (M.Y.).
Insights
Systematic screening for atrial fibrillation using electrocardiograms significantly reduced stroke risk in older adults. This approach proved effective in identifying and managing atrial fibrillation, preventing major adverse cardiovascular events.
Area of Science:
- Cardiology
- Preventive Medicine
- Clinical Trials
Background:
- Atrial fibrillation is a common arrhythmia that increases stroke risk.
- Early detection and treatment of atrial fibrillation can prevent ischemic strokes.
- Systematic screening strategies for atrial fibrillation are being investigated.
Purpose of the Study:
- To evaluate the effectiveness of systematic screening for atrial fibrillation in reducing stroke incidence.
- To compare clinical outcomes between systematic screening and usual care for atrial fibrillation.
Main Methods:
- A multicenter, parallel-group, unmasked, randomized controlled trial was conducted.
- Participants underwent systematic screening for atrial fibrillation using electrocardiograms.
- Control group received usual care for atrial fibrillation detection and management.
Main Results:
- Systematic screening significantly reduced the risk of stroke compared to usual care.
- The number of participants experiencing stroke was lower in the screening group.
- No significant differences in major adverse cardiovascular events were observed between groups.
Conclusions:
- Systematic screening for atrial fibrillation is an effective strategy for stroke prevention.
- This approach can lead to earlier diagnosis and management of atrial fibrillation.
- Healthcare providers should consider implementing systematic screening for atrial fibrillation in at-risk populations.
Source Citation:
Svennberg E, Friberg L, Frykman V, et al. Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial. Lancet. 2021;398:1498-1506. 34469764.
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