Bisphenol-A analogs induce lower urinary tract dysfunction in male mice
J L Nguyen1, E A Ricke1, T T Liu1
1Dept of Urology, University of Wisconsin, Madison, WI 53719, United States.
Biochemical Pharmacology
|January 3, 2022
Summary
Bisphenol exposure, including BPA and its replacements BPS and BPF, causes lower urinary tract dysfunction (LUTD) in male mice. This study links these chemicals to prostate and bladder changes, suggesting a role in human BPH/LUTS.
Area of Science:
- Endocrinology
- Toxicology
- Urology
Background:
- Bisphenol-A (BPA) is an endocrine disruptor affecting mammalian health.
- Estrogens influence prostate biology, but the role of bisphenols in prostate pathology is unclear.
- Bisphenol-F (BPF) and Bisphenol-S (BPS) are BPA substitutes with potent estrogenic effects.
Purpose of the Study:
- To investigate the role of BPA, BPF, and BPS in the development of lower urinary tract dysfunction (LUTD) in adult male mice.
- To assess the impact of bisphenol exposure on urinary tract histopathology and physiological function.
Main Methods:
- Adult male mice were exposed to BPA, BPF, or BPS.
- Urinary tract histopathology and cystometric evaluations were performed.
- Voiding function and prostatic urethra changes were analyzed.
Main Results:
- Bisphenol exposure led to increased bladder and prostate mass.
- Prostatic urethra showed more ducts and a smaller lumen.
- Cystometry revealed detrusor instability and voiding dysfunction consistent with LUTD.
Conclusions:
- BPA and its analogs (BPF, BPS) are implicated in the development of LUTD in mice.
- These findings suggest a potential role for bisphenols in benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in men.
