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Updated: Oct 8, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Intravascular Large B-Cell Lymphoma
Joshua W Davis1, Aaron Auerbach2, Barbara A Crothers2
1From the Clinical and Anatomic Pathology Residency Program, Walter Reed National Military Medical Center, Bethesda, Maryland (Davis).
Context.—:
Intravascular large B-cell lymphoma (IVLBCL) is a rare hematopathologic entity, posing both a clinical and histologic challenge for diagnosis. Numerous pitfalls can hinder making the diagnosis.
Objective.—:
To summarize recent developments in literature pertaining to IVLBCL and point out key pitfalls pathologists should be prepared to encounter.
Data Sources.—:
Literature review via PubMed search and hospital (Darnall Medical Library) resources.
Conclusions.—:
The 3 primary pitfalls of IVLBCL include masking of IVLBCL, mimicry by IVLBCL, and mimicry of IVLBCL. These scenarios illustrate the importance of histologic pattern recognition and subsequent usage of immunohistochemistry, especially in context of a clinical history that may be noncharacteristic.
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