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Published on: March 30, 2018
Intravascular Large B-Cell Lymphoma
Joshua W Davis1, Aaron Auerbach2, Barbara A Crothers2
1From the Clinical and Anatomic Pathology Residency Program, Walter Reed National Military Medical Center, Bethesda, Maryland (Davis).
Intravascular large B-cell lymphoma (IVLBCL) presents diagnostic challenges due to its rarity. Pathologists must recognize pitfalls like masking and mimicry, utilizing histology and immunohistochemistry for accurate IVLBCL diagnosis.
Area of Science:
- Hematopathology
- Oncology
- Diagnostic Pathology
Background:
- Intravascular large B-cell lymphoma (IVLBCL) is a rare hematologic malignancy.
- Diagnosis is challenging due to clinical and histologic complexities.
- Several diagnostic pitfalls can impede accurate identification of IVLBCL.
Purpose of the Study:
- To review recent literature on IVLBCL.
- To highlight critical diagnostic challenges and pitfalls for pathologists.
- To improve the diagnostic accuracy of IVLBCL.
Main Methods:
- Comprehensive literature review utilizing PubMed.
- Inclusion of resources from Darnall Medical Library.
- Analysis of diagnostic scenarios and pitfalls in IVLBCL.
Main Results:
- Identified three primary diagnostic pitfalls: masking of IVLBCL, mimicry by IVLBCL, and mimicry of IVLBCL.
- Emphasized the crucial role of histologic pattern recognition.
- Highlighted the necessity of immunohistochemistry in challenging cases.
Conclusions:
- Accurate diagnosis of IVLBCL requires careful consideration of its rarity and potential for misdiagnosis.
- Histologic pattern recognition is paramount.
- Immunohistochemistry is essential, particularly when clinical presentation is atypical.
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