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Updated: Oct 8, 2025
26:48
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
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Chronic Pregabalin Abuse with Subacute Encephalopathy Mimicking Autoimmune Encephalitis
Kamble Jayaprakash Harsha1, E V Joshy1, Rangenahalli Vasudev Aravinda1
1Department of Clinical Neurosciences, Division of Neurology, BRAINS - Brain Spine Centre, #146, Infantry Road, Bangalore, Karnataka, India.
Neurology India
|January 4, 2022
Summary
This case study highlights how chronic pregabalin abuse can cause neurological symptoms and MRI changes that mimic autoimmune encephalitis. Complete recovery occurred after discontinuing pregabalin.
Area of Science:
- Neurology
- Neuroscience
- Radiology
Background:
- Pregabalin, a gabapentinoid, is commonly prescribed for neuropathic pain.
- Increasing reports indicate pregabalin is also a drug of abuse.
Observation:
- A 31-year-old man presented with subacute neuropsychiatric symptoms and movement disorders.
- Initial treatment for suspected autoimmune encephalitis showed temporary improvement, followed by symptom recurrence.
- Magnetic Resonance Imaging (MRI) revealed parenchymal changes, yet autoimmune encephalitis markers were negative.
Findings:
- The patient confessed to chronic pregabalin abuse.
- Cessation of pregabalin abuse led to complete symptom resolution and recovery.
- This is the first reported case of MRI parenchymal changes mimicking autoimmune encephalitis due to pregabalin abuse.
Implications:
- The findings suggest pregabalin abuse can cause significant neurological and radiological abnormalities.
- Consideration should be given to restricting pregabalin availability, especially in regions with lax dispensing practices.
- Increased awareness among clinicians and pharmacists regarding pregabalin abuse is crucial.
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