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[Next-generation diagnostic pathology].

X W Bian1, P P Zhang2, Y F Ping1

  • 1Institute of Pathology, Southwest Hospital, Third Military Medical University(Army Medical University)/Key Laboratory of Tumor Immunopathology, Ministry of Education, Chongqing 400038, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
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Summary

Next-Generation Diagnostic Pathology (NGDP) integrates molecular data and AI for precise disease diagnosis and treatment. This approach aims to establish a new standard in pathology, improving patient outcomes and advancing clinical medicine.

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Area of Science:

  • Pathology
  • Bioinformatics
  • Genomics
  • Artificial Intelligence

Background:

  • Clinical medicine is advancing towards precision diagnosis and treatment.
  • Traditional diagnostic pathology faces new opportunities and challenges.
  • The development of human genome sequencing, bioinformatics, and AI-assisted diagnosis drives this evolution.

Purpose of the Study:

  • To introduce the concept and characteristics of Next-Generation Diagnostic Pathology (NGDP).
  • To highlight the integration of innovative technologies in pathology.
  • To outline the potential of NGDP in disease diagnosis, treatment, and patient management.

Main Methods:

  • NGDP integrates histomorphology, clinical data, molecular detection, and bioinformatics analysis.
  • It incorporates intelligent sampling, quality control, AI-assisted diagnosis, and remote consultation.
  • Lesion visualization and non-invasive pathology techniques are key components.

Main Results:

  • NGDP reports will feature multi-omics and cross-scale integrated diagnoses.
  • It will enable prediction of disease progression, outcomes, and treatment responses.
  • NGDP aims to establish a novel "golden standard" for disease diagnosis.

Conclusions:

  • NGDP represents a significant evolution from traditional pathology.
  • Accelerating the adoption of NGDP is crucial for advancing clinical medicine and public health.
  • Further development is needed to update pathology's theoretical and technical systems for its application in disease prevention and treatment.