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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
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Related Experiment Video

Updated: Oct 8, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Genome-wide association studies for growth traits in broilers.

Dachang Dou1, Linyong Shen1, Jiamei Zhou1

  • 1Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province; College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, P. R. China.

BMC Genomic Data
|January 4, 2022
PubMed
Summary

Identifying genetic markers and genes for broiler growth traits aids selection and understanding. This study found 113 quantitative trait nucleotides and key genes linked to rapid broiler growth.

Keywords:
Body weightBroilerGWASGrowth traitHeritability

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Area of Science:

  • Animal Genetics
  • Quantitative Genetics
  • Poultry Science

Background:

  • Understanding the genetic basis of growth traits in broilers is crucial for improving livestock.
  • Marker-assisted selection and genomic selection rely on identifying relevant genetic markers and genes.

Purpose of the Study:

  • To estimate genetic parameters for eight growth traits in broilers.
  • To conduct genome-wide association studies (GWAS) for these growth traits.
  • To identify candidate genes associated with rapid growth in broilers.

Main Methods:

  • Estimation of genetic parameters for eight growth traits.
  • Genome-wide association studies (GWAS) were performed.
  • Multiple methods were used to discover quantitative trait nucleotides (QTNs).

Main Results:

  • Genetic parameters for eight broiler growth traits were estimated.
  • A total of 113 QTNs were identified through various methods.
  • Several candidate genes (e.g., ACTA1, IGF2BP1, TGFBR2) were identified as important for rapid broiler growth.

Conclusions:

  • The identified markers and genes provide valuable insights into the genetic architecture of broiler growth.
  • This information can enhance marker-assisted selection and genomic selection strategies in poultry breeding.
  • The study contributes to a deeper understanding of the genetic foundation of growth traits in broilers.