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Updated: Oct 8, 2025
Identification of Mycobacterium Species by DNA Microarray Chip Method
Published on: June 24, 2025
High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens
1Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, 35/39, I-56127, Pisa, Italy.
Background:
M. intracellulare is a frequent causative pathogen of nontuberculous mycobacteria infection that causes infections in the respiratory tract, whose incidence is increasing in many countries. This study aimed at determining the VNTR-based genetic diversity of a collection of 39 M. intracellulare human strains isolated from respiratory specimens over the last 5 years.
Results:
The VNTR analysis showed that M. intracellulare strains displayed a high genetic diversity, indicating that the M. intracellulare genotypes are quite heterogeneous in our geographical area. Moreover, a comparison with VNTR profiles of strains from other countries confirmed that genotypes of clinical strains of M. intracellulare are not related to geographical origin.
Conclusions:
VNTR typing has proved to be a highly discriminatory method for better understanding the molecular epidemiology of M. intracellulare.
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