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[Olmesartan-associated Enteropathy]

Long Zou1, Qiang Wang1, Yue Li1

  • 1Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|January 4, 2022
PubMed

Insights

Olmesartan, an antihypertensive drug, can cause severe gastrointestinal issues like chronic diarrhea and weight loss, known as olmesartan-associated enteropathy. Patients recover after stopping the medication, broadening differential diagnoses for malabsorption syndromes.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Internal Medicine

Background:

  • Olmesartan is a widely prescribed angiotensin II receptor blocker for hypertension.
  • Recent studies link olmesartan use to severe gastrointestinal adverse events.
  • These events include chronic diarrhea, intestinal malabsorption, and weight loss.

Purpose of the Study:

  • To review the potential pathogenesis of olmesartan-associated enteropathy (OAE).
  • To describe the clinical characteristics of OAE.
  • To enhance the differential diagnosis of chronic diarrhea and malabsorption.

Main Methods:

  • Review of case reports and cohort studies.
  • Analysis of clinical presentations and patient outcomes.
  • Discussion of proposed pathophysiological mechanisms.

Main Results:

  • Olmesartan administration is associated with a distinct enteropathy (OAE).
  • Symptoms include severe diarrhea, malabsorption, and weight loss.
  • Discontinuation of olmesartan leads to patient recovery.

Conclusions:

  • OAE is a significant adverse effect of olmesartan therapy.
  • Recognizing OAE is crucial for accurate diagnosis of unexplained GI symptoms.
  • This review expands the understanding of drug-induced enteropathies.
Keywords:
adverse eventchronic diarrheaintestinal malabsorptionolmesartan

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