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Macrophage polarisation in caesarean scar diverticulum
Jinfa Huang1, Xiaochun Liu2, Yi Hou3
1Department of Gynecology, Shunde Hospital of Southern Medical University, Foshan, Guangdong, China.
Journal of Clinical Pathology
|January 4, 2022
Summary
Post-caesarean scar diverticulum (CSD) tissues show increased inflammation, fibrosis, and neovascularisation markers compared to normal caesarean section tissues. Macrophage polarisation may drive CSD development and severity.
Area of Science:
- Reproductive medicine
- Immunohistochemistry
- Pathology
Background:
- Post-caesarean scar diverticulum (CSD) is a complication of caesarean section.
- Understanding the underlying pathophysiology of CSD is crucial for effective management.
Purpose of the Study:
- To investigate the immunohistochemical features of CSD.
- To correlate M1/M2 macrophage polarisation status with CSD disease severity.
Main Methods:
- Histological and immunohistochemical analyses were performed on uterine tissues from patients with CSD (n=37) and controls (n=3).
- Markers for inflammation (CD16, CD163, TNF-α), fibrosis (α-SMA), and angiogenesis (CD31) were examined.
Main Results:
- CSD tissues exhibited higher expression of α-SMA, TNF-α, CD16, and CD31, and lower CD163 expression compared to control tissues.
- Significant correlations were found between CD16 expression, the CD16/CD163 ratio, and markers of inflammation, fibrosis, and neovascularisation in CSD tissues.
Conclusions:
- Overexpression of TNF-α, α-SMA, CD16, and CD31 was observed in CSD cases.
- The CD16/CD163 ratio correlated positively with tissue inflammation, fibrosis, and neovascularisation, suggesting a role for abnormal macrophage infiltration in CSD pathogenesis.
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