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Magnetic Field-Responsive Pulsatile Drug Release Using A Magnetic Fluid.

Chihiro Takei1, Kenji Mori1, Takeshi Oshizaka1

  • 1Faculty of Pharmaceutical Sciences, Josai International University.

Chemical & Pharmaceutical Bulletin
|January 4, 2022
PubMed
Summary

Magnetic injectable formulations using ferrofluids enabled pulsatile drug release. White petrolatum-based preparations showed magnetic field-responsive lidocaine hydrochloride release, enhanced by hydrophilic cream.

Keywords:
depot formulationhydrophilic drugmagnetic field-responsive releasemagnetic fluidpulsatile release

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Ferrofluids are colloidal liquids containing magnetic nanoparticles that alter shape and fluidity under external magnetic fields.
  • Pulsatile drug delivery systems aim to release therapeutic agents in a controlled, on-demand manner.
  • Injectable formulations offer minimally invasive drug administration routes.

Purpose of the Study:

  • To investigate the magnetic field-responsive pulsatile release of lidocaine hydrochloride (LID·HCl) from injectable depot formulations.
  • To evaluate the influence of ferrofluid concentration and vehicle composition (white petrolatum and hydrophilic cream) on drug release kinetics.
  • To explore the potential of these formulations for controlled drug delivery applications.

Main Methods:

  • Development of depot-type injectable formulations incorporating ferrofluids, white petrolatum, and/or hydrophilic cream.
  • Utilized a self-made diffusion cell to assess drug release under the influence of a moving external magnetic field.
  • Quantified the release of lidocaine hydrochloride (LID·HCl) as a model drug.

Main Results:

  • Magnetic field-responsive release of LID·HCl was observed exclusively in preparations containing white petrolatum.
  • The extent of magnetic field-responsive release was dependent on the concentration of the magnetic fluid within the white petrolatum formulation.
  • Formulations combining white petrolatum and hydrophilic cream exhibited enhanced magnetic field-responsive release compared to white petrolatum alone; no responsiveness was seen with hydrophilic cream solely.
  • No magnetic field responsiveness was observed in preparations containing only hydrophilic cream.

Conclusions:

  • Injectable ferrofluid-based formulations, particularly those incorporating white petrolatum, can achieve magnetic field-responsive pulsatile drug release.
  • The combination of white petrolatum and hydrophilic cream optimizes the magnetic responsiveness of the injectable system.
  • These findings suggest a promising avenue for developing novel injectable formulations capable of pulsatile administration, potentially for macromolecular drugs.