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Self-limited Polymyalgia Rheumatica-like Syndrome Following mRNA-1273 SARS-CoV-2 Vaccination

Shinji Izuka1, Toshihiko Komai1, Bunki Natsumoto1

  • 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Japan.

Internal Medicine (Tokyo, Japan)
|January 4, 2022
PubMed

Insights

Polymyalgia rheumatica-like syndrome occurred after mRNA-1273 vaccination. Symptoms resolved within a month without medication, suggesting a transient post-vaccination inflammatory response.

Area of Science:

  • Rheumatology
  • Immunology
  • Vaccinology

Background:

  • Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disease affecting shoulders, neck, and hips.
  • PMR pathogenesis involves myeloid lineage activation and pattern recognition receptor expression.
  • mRNA-1273 vaccination activates innate immunity, acting as an immunogen and adjuvant.

Purpose of the Study:

  • To report the first case of a polymyalgia rheumatica-like syndrome following mRNA-1273 vaccination.
  • To describe the clinical presentation and resolution of this syndrome.

Main Methods:

  • Case report of a patient experiencing PMR-like symptoms after mRNA-1273 vaccination.
  • Monitoring of clinical symptoms and inflammatory markers.

Main Results:

  • A PMR-like syndrome developed seven days post-mRNA-1273 vaccination.
  • Symptoms included neck, shoulder, and pelvic girdle pain with elevated inflammatory markers.
  • Resolution of symptoms and inflammatory markers occurred within one month without immunosuppressants.

Conclusions:

  • mRNA-1273 vaccination can transiently trigger a PMR-like syndrome.
  • This syndrome appears to resolve spontaneously without specific treatment.
  • Further investigation into vaccine-induced inflammatory syndromes is warranted.
Keywords:
COVID-19SARS-CoV-2giant cell arteritispolymyalgia rheumaticavaccine

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