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Related Experiment Video

Updated: Oct 8, 2025

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[Drug repositioning to combat COVID-19 using artificial intelligence system].

Norihisa Shindo1, Hiroyoshi Toyoshiba1

  • 1Life Science AI, FRONTEO, Inc.

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|January 4, 2022
PubMed
Summary

Artificial intelligence identified key genes and potential drugs for treating COVID-19 (coronavirus disease 2019). This AI-driven drug repositioning approach offers new therapeutic strategies for the ongoing pandemic.

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Area of Science:

  • Biomedical Informatics
  • Computational Biology
  • Drug Discovery

Background:

  • The COVID-19 pandemic necessitates urgent development of effective treatments.
  • The rapid pace of research makes comprehensive literature review challenging.
  • Existing drug options for COVID-19 are limited.

Purpose of the Study:

  • To accelerate drug repositioning for COVID-19 using artificial intelligence.
  • To identify key genes and potential therapeutic targets for COVID-19.
  • To explore existing drugs that could be repurposed for COVID-19 treatment.

Main Methods:

  • Utilized a patented AI system, Concept Encoder, based on natural language processing.
  • Deeply learned scientific papers related to COVID-19.
  • Generated a molecular linkage map of COVID-19 pathogenesis by connecting implicated genes.
  • Ranked genes and identified potential drug targets.

Main Results:

  • Identified a significant group of genes involved in COVID-19 pathogenesis.
  • Constructed a molecular linkage map illustrating gene interrelationships in COVID-19.
  • Discovered potential key genes driving disease progression.
  • Found existing drugs that may improve outcomes for COVID-19 patients.

Conclusions:

  • AI-powered drug repositioning can significantly accelerate the identification of COVID-19 treatments.
  • The Concept Encoder system provides a valuable tool for understanding disease mechanisms and discovering repurposable drugs.
  • This approach highlights potential therapeutic targets and existing medications for improving COVID-19 survival.