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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Cross-reactivity00:42

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Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Related Experiment Video

Updated: Oct 8, 2025

Measuring Local Anaphylaxis in Mice
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[Anaphylaxis and COVID-19 vaccines].

M Castells1, P Demoly2,3,4, L K Tanno2,3,4

  • 1Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Massachusetts, États-Unis.

Revue Francaise D'Allergologie (2009)
|January 4, 2022
PubMed
Summary

Anaphylaxis after COVID-19 vaccination is rare, occurring at 2.5-11 cases per million. Early recognition and treatment with epinephrine are crucial for managing reactions and enabling safe re-vaccination for most individuals.

Keywords:
Adverse reactionAllergyAnaphylaxisCOVID-19Polyethylene-glycolSARS-COVID vaccineVaccine

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Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Context:

  • COVID-19 vaccines are critical global health tools.
  • Anaphylactic reactions are a rare but reported adverse event following SARS-CoV-2 RNA vaccination.
  • Vaccine safety surveillance programs are essential for monitoring severe adverse reactions.

Purpose:

  • To assess the incidence and characteristics of anaphylaxis following COVID-19 vaccination.
  • To provide guidance on the recognition, treatment, and management of anaphylaxis in vaccinated individuals.
  • To reinforce confidence in the safety and efficacy of COVID-19 vaccines.

Summary:

  • Anaphylaxis risk post-COVID-19 vaccination is estimated at 2.5-11 per million, with polyethylene glycol implicated in rare instances.
  • Immediate treatment with epinephrine is effective, and most patients, including those with a history of allergies, can be safely re-vaccinated with pre-medication.
  • Recognizing at-risk populations, such as individuals with allergy histories or mast cell activation diseases, is vital for personalized care.

Impact:

  • Ensuring continued public trust and uptake of COVID-19 vaccination programs.
  • Guiding healthcare providers in the immediate management of anaphylactic reactions.
  • Highlighting the critical role of allergists in managing rare vaccine complications and facilitating re-vaccination strategies.