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Anatomical Association Between Schizophrenia and Cerebellum
Rajashekar Reddy Yeruva1,2, Yafei Shang1,2, Ben Schoenbachler1,2
1Dr. Yeruva is with Baylor Scott and White Medical Center in Round Rock, Texas.
Innovations in Clinical Neuroscience
|January 4, 2022
Summary
Schizophrenia pathogenesis may involve the cerebellum, not just the cerebrum. A case study suggests cerebellar tumor disruption of the cortico-cerebellar-thalamic-cortical circuit (CCTCC) worsened psychosis.
Area of Science:
- Neuroscience
- Psychiatry
- Oncology
Background:
- Schizophrenia pathogenesis is typically linked to cerebral dysfunction.
- The cerebellum's role in cognitive processes and a cortico-cerebellar-thalamic-cortical circuit (CCTCC) mediating these functions have been proposed.
- Cerebellar dysfunction is rarely considered in schizophrenia.
Observation:
- A 31-year-old male with a family history of psychosis developed schizophrenia.
- The patient had a slow-growing glioblastoma at the left posterior cerebellar pontine angle.
- Surgical removal of the tumor, without motor deficits, led to refractory psychosis.
Findings:
- The patient's psychosis worsened post-surgery, suggesting disruption of the CCTCC.
- This disruption may be linked to the glioblastoma's impact on the cortico-cerebellar-thalamic-cortical circuit.
- The case highlights a potential link between cerebellar pathology and schizophrenia.
Implications:
- Supports the hypothesis of cognitive dysmetria in schizophrenia.
- Suggests the cerebellum and CCTCC are critical in mental process coordination.
- Underscores the need to consider cerebellar involvement in schizophrenia pathogenesis.
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