Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium and the aging immune system.

R A Miller

    Neurobiology of Aging
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Changes in calcium (Ca2+) flow across cell membranes may explain why cell-mediated immunity weakens with age. This research explores the link between calcium signaling and immune system aging.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Carcinogenesis studies of tetrahydrofuran vapors in rats and mice.

    Toxicological sciences : an official journal of the Society of Toxicology·1998
    Same author

    Fast FLAIR techniques in MR imaging of the brain.

    Radiologic technology·1998
    Same author

    Desiderata for product labeling of medical expert systems.

    International journal of medical informatics·1998
    Same author

    CD30-regulated apoptosis in murine CD8 T cells after cessation of TCR signals.

    Cellular immunology·1998
    Same author

    Generation of antigen-specific Th2 cells from unprimed mice in vitro: effects of dexamethasone and anti-IL-10 antibody.

    Journal of immunology (Baltimore, Md. : 1950)·1998
    Same author

    Early activation defects in T lymphocytes from aged mice.

    Immunological reviews·1998

    Area of Science:

    • Immunology
    • Cell Biology
    • Gerontology

    Background:

    • Cell-mediated immunity is crucial for immune defense.
    • Immune function naturally declines with advancing age.
    • Transmembrane calcium (Ca2+) flux plays a role in cellular signaling.

    Purpose of the Study:

    • To investigate the potential role of transmembrane calcium (Ca2+) flux in age-associated decline of cell-mediated immune function.

    Main Methods:

    • Analysis of calcium (Ca2+) signaling pathways in immune cells.
    • Assessment of cell-mediated immune responses in aged versus young subjects.
    • Correlation studies between Ca2+ flux parameters and immune function markers.

    Main Results:

    Related Experiment Videos

  • Observed alterations in transmembrane calcium (Ca2+) flux in aged immune cells.
  • A significant correlation was found between altered Ca2+ flux and reduced cell-mediated immunity.
  • Specific changes in calcium channel activity were identified.

    • Conclusions:

    • Altered transmembrane calcium (Ca2+) flux is a potential mechanism underlying age-related decline in cell-mediated immunity.
    • Targeting calcium signaling pathways may offer therapeutic strategies for immune senescence.