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Developmental hemostasis in the neonatal period
Vicente Rey Y Formoso1, Ricardo Barreto Mota2, Henrique Soares2,3
1Neonatology Department (Reference Center for Congenital Heart Diseases), São João University Hospital Center, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal. jose.formoso@chsj.min-saude.pt.
World Journal of Pediatrics : WJP
|January 4, 2022
Summary
Neonatal hemostasis differs significantly from adults due to developmental hemostasis. Understanding these age-related changes is crucial for pediatric care.
Area of Science:
- Hematology
- Pediatrics
- Developmental Biology
Background:
- The hemostatic system undergoes continuous evolution from gestation through adulthood, termed "developmental hemostasis."
- Neonatal hemostasis presents unique characteristics distinct from older children and adults.
Purpose of the Study:
- To review the characteristics of developmental hemostasis in the neonatal period.
- To describe age-related progression of hemostatic system components.
- To explore potential physiological reasons for these developmental changes.
Main Methods:
- Comprehensive literature review utilizing PubMed/MEDLINE.
- Inclusion of relevant cross-references on developmental hemostasis.
Main Results:
- Hemostatic system components exhibit distinct quantitative and qualitative age-related differences.
- Neonatal coagulation systems show significant disparities compared to adults, yet maintain physiological balance.
- The underlying reasons for these differences are not fully understood but may involve non-hemostatic factors.
Conclusions:
- Knowledge of developmental hemostasis is vital for healthcare providers caring for newborns and children.
- This review details neonatal hemostatic component characteristics and their progression.
- Potential physiological drivers of developmental hemostasis are discussed.
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