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Elevated levels of a lymphocyte subset accurately predict the diabetic state in the BB rat
The frequency of Ia antigen bearing W3/13 positive lymphocytes from the blood of 68 bio-breeding (BB) diabetes-prone rats was analyzed with monoclonal antibodies to determine whether elevated levels of these cells could predict which animals would subsequently become hyperglycemic. Selecting a value of greater than or equal to 4.00% as elevated, the sensitivity of this assay in predicting diabetes was 85%, while the specificity was 83%. We believe that elevated levels of Ia antigen bearing W3/13 positive lymphocytes reflect an ongoing immune process and accurately predict the likelihood of developing spontaneous hyperglycemia when obtained from a high risk population.
The frequency of Ia antigen bearing W3/13 positive lymphocytes from the blood of 68 bio-breeding (BB) diabetes-prone rats was analyzed with monoclonal antibodies to determine whether elevated levels of these cells could predict which animals would subsequently become hyperglycemic. Selecting a value of greater than or equal to 4.00% as elevated, the sensitivity of this assay in predicting diabetes was 85%, while the specificity was 83%. We believe that elevated levels of Ia antigen bearing W3/13 positive lymphocytes reflect an ongoing immune process and accurately predict the likelihood of developing spontaneous hyperglycemia when obtained from a high risk population.