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Liver Transplant in Hemoglobin SC Disease and Autoimmune Hepatitis: A Case Report

Ahyoung Kim1, Naziheh Assarzadegan, Robert A Anders

  • 1From the Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|January 4, 2022
PubMed

Insights

Liver transplantation is feasible for patients with sickle cell disease (HbSC genotype) and cirrhosis. Careful multidisciplinary care is crucial for managing complex postoperative complications in these patients.

Area of Science:

  • Hepatology
  • Hematology
  • Transplant Surgery

Background:

  • Liver transplantation is a critical treatment for end-stage liver disease.
  • Perioperative management of liver transplant recipients with sickle cell disease presents unique challenges.

Observation:

  • A 50-year-old man with sickle cell disease (HbSC genotype) and autoimmune hepatitis-induced cirrhosis underwent liver transplantation.
  • The patient experienced postoperative complications including deep vein thrombosis, pulmonary embolism, stroke, and posterior reversible encephalopathy syndrome.

Findings:

  • Despite complications, the patient survived with a functioning liver graft 10 months post-transplant.
  • This case demonstrates the viability of liver transplantation in sickle cell disease patients.

Implications:

  • Meticulous multidisciplinary care is essential for successful liver transplantation in patients with sickle cell disease.
  • Consideration of autoimmune hepatitis and sickle cell disease is vital for transplant planning and management.

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