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Anti-Interleukin 6 Therapeutics for Chronic Antibody-Mediated Rejection In Kidney Transplant Recipients

Rajeev Sharma1

  • 1From the Michael and Marian Ilitch Department of Surgery, Wayne Health, Detroit, Michigan, USA.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|January 4, 2022
PubMed

Insights

New treatments targeting interleukin 6 are being explored for chronic antibody-mediated rejection, a major cause of kidney transplant failure. These novel therapies offer hope where current treatments lack efficacy.

Area of Science:

  • Nephrology
  • Immunology
  • Transplantation

Background:

  • Chronic antibody-mediated rejection (AMR) is the leading cause of late kidney allograft loss.
  • Current standard treatments lack robust scientific evidence and have limited success rates.
  • There is an urgent need for effective therapies for chronic AMR.

Purpose of the Study:

  • To review the biologic basis of interleukin 6 (IL-6) inhibitors.
  • To evaluate the safety and efficacy of IL-6 inhibitors for treating chronic AMR in kidney transplant recipients.

Main Methods:

  • Literature review focusing on IL-6 biology and clinical trial data.
  • Analysis of safety and efficacy profiles of tocilizumab and clazakizumab.

Main Results:

  • IL-6 plays a significant role in the pathogenesis of chronic AMR.
  • Early clinical data suggest potential safety and efficacy of IL-6 inhibitors.

Conclusions:

  • Interleukin 6 inhibitors represent a promising therapeutic strategy for chronic antibody-mediated rejection.
  • Further clinical trials are warranted to establish the role of IL-6 inhibitors in kidney transplantation.

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