Related Experiment Video
Updated: Oct 8, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
[Retracted] Function of miR‑152 as tumor suppressor in oral squamous cell carcinoma cells by targeting c‑MET
Minghe Li1, Zhihong Li2, Xue Wang3
1Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China.
Abstract:
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the representative tumor images shown in Fig. 6B were strikingly similar to images appearing in different form in another article by different authors. Subsequently to the comments raised by the reader, the authors themselves contacted the Editorial Office to request a retraction of the above paper on account of not being to reproduce the results shown in the in vivo experiments. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to Oncology Reports, and in line with the authors' own request, the Editor has decided that this paper should be retracted from the Journal. The Editor apologizes to the readership for any inconvenience caused. [the original article was published in Oncology Reports 39: 1173‑1180, 2018; DOI: 10.3892/or.2017.6157].
Insights
This paper on tumor imaging and in vivo experiments has been retracted due to image similarities and irreproducible results. The authors requested retraction after discovering issues with the published data.
Area of Science:
- Oncology
- Biomedical Research
- Scientific Publishing
Context:
- Concerns were raised regarding image duplication in Fig. 6B.
- Authors reported inability to reproduce in vivo experimental results.
Purpose:
- To address concerns about data integrity and reproducibility.
- To formally retract a published scientific paper.
Summary:
- Representative tumor images in Fig. 6B were found to be similar to those in another publication.
- Authors could not replicate in vivo findings, leading to a retraction request.
- The paper is retracted because the data was previously published and results were irreproducible.
Impact:
- Retraction upholds scientific integrity and standards.
- Ensures accurate dissemination of research findings.
- Alerts the scientific community to the issues with the published data.
Related Concept Videos
MicroRNAs
Abnormal Proliferation
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Mitogens and the Cell Cycle
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

