Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

491
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
491
Analgesia and Pain Management01:25

Analgesia and Pain Management

907
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
907
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

442
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
442
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

870
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
870
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

519
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
519
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

910
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
910

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Appropriate translational designs for determining causal force-based (manual therapy) treatment mechanisms.

Musculoskeletal science & practiceĀ·2026
Same author

Many Paths to Recovery: The Case for Treatment Pluralism.

The Journal of orthopaedic and sports physical therapyĀ·2026
Same author

Modern teaching for clinical education involving manual therapy: a 6-pillar approach.

Chiropractic & manual therapiesĀ·2026
Same author

Evaluating the integration of the reported treatment mechanisms and goal of treatment in randomized controlled trials for low back pain: protocol for a meta-epidemiological analysis.

Journal of clinical epidemiologyĀ·2026
Same author

An independent validation of a clinical prediction rule for the diagnosis of cervical radiculopathy with radicular pain.

Brazilian journal of physical therapyĀ·2026
Same author

Exercise-Induced Hypoalgesia Following Blood Flow Restriction in Rotator Cuff Repair Rehabilitation: A Randomized Crossover Clinical Trial.

Translational sports medicineĀ·2026
Same journal

Recombinant Humanized Type III Collagen Enhances Fat Graft Retention by Promoting Angiogenesis and Adipocyte Viability in a Nude Mouse Model.

Aesthetic surgery journalĀ·2026
Same journal

Beyond the Fixed Grid: Precision-guided Botulinum Toxin Treatment for Primary Axillary Hyperhidrosis.

Aesthetic surgery journalĀ·2026
Same journal

Buccal Fat Suspension: Not Just a Lift-Restoring the Foundational Anatomy of a Youthful Cheek.

Aesthetic surgery journalĀ·2026
Same journal

Adverse Outcomes and Complications of Autologous Versus Homologous Costal Cartilage Grafts in Septorhinoplasty: A Systematic Review and Meta-analysis.

Aesthetic surgery journalĀ·2026
Same journal

Porous Architecture and Pressure-Induced Latent Injury: New Insights into Large-Volume Fat Grafting.

Aesthetic surgery journalĀ·2026
Same journal

Extending the Private Equity Conversation in Aesthetic Surgery.

Aesthetic surgery journalĀ·2026
See all related articles

Related Experiment Video

Updated: Oct 8, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.9K

Precise Analgesic Instructions Improve Narcotic Usage: A Randomized Trial.

Logan Erz1, Brandon Larson1, Shayda Mirhaidari2

  • 1Department of General Surgery, Akron City Hospital, Akron, OH, USA.

Aesthetic Surgery Journal
|January 4, 2022
PubMed
Summary
This summary is machine-generated.

Providing explicit pain management instructions significantly reduced opioid use and pain scores in breast reduction patients. This strategy may decrease narcotic prescriptions without impacting pain control.

More Related Videos

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

33.6K
Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.4K

Related Experiment Videos

Last Updated: Oct 8, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.9K
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

33.6K
Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.4K

Area of Science:

  • Plastic Surgery
  • Pain Management
  • Pharmacology

Background:

  • The United States faces significant challenges with opioid abuse and overuse.
  • New strategies are needed to reduce opioid utilization and overprescribing.

Purpose of the Study:

  • To evaluate if a regulated, explicit pain management instruction plan can decrease opioid consumption.

Main Methods:

  • A blinded, randomized prospective study involved 110 women undergoing bilateral breast reduction.
  • Group A (control) received general pain instructions; Group B (experimental) received explicit instructions.
  • Participants self-reported opioid use and pain scores.

Main Results:

  • Group B patients used an average of 1.5 (5 mg) oxycodone tablets, compared to 5.7 in Group A (P < 0.01).
  • 34 patients in Group B used no oxycodone.
  • Group B reported significantly lower subjective pain scores.

Conclusions:

  • Standardized postoperative pain management instructions may reduce the need for narcotics.
  • This approach can decrease opioid prescribing without compromising patient pain control.