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Updated: Oct 8, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
[Chronic Fatigue: When to Suspect an Inherited Metabolic Disease?]
Aurel T Tankeu1, Christel Tran1
1Centre des maladies moléculaires (CMM), Service de Médecine Génétique, Centre Hospitalier et Universitaire Vaudois (CHUV), Lausanne.
Abstract:
Chronic Fatigue: When to Suspect an Inherited Metabolic Disease? Abstract. Chronic fatigue is a non-specific symptom, frequent in outpatient adults' consultations. Persistent physical fatigue of unknown etiology should prompt the search for rare diseases including inherited metabolic disorder (IMD) after elimination of common causes. The main characteristic of chronic fatigue in IMD is its dynamic nature, worsened by circumstances leading to an increased metabolism such as physical exertion, cold, fasting or infection. IMD leading to chronic fatigue are metabolic myopathies, in particular glycogen storage disease affecting muscle, fatty acid oxidation disorders and mitochondrial diseases. The diagnosis is confirmed by specific biochemical and/or molecular analyzes with multidisciplinary management.
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