Immunometabolism in the Bladder Cancer Microenvironment.
Mohammad Javad Fattahi1, Mohammad Reza Haghshenas1, Abbas Ghaderi1,2
1School of Medicine, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
Endocrine, Metabolic & Immune Disorders Drug Targets
|January 5, 2022
Summary
Bladder cancer progression relies on its tumor microenvironment (TME). Understanding immunometabolism in the TME offers new therapeutic strategies for bladder cancer (BC).
Area of Science:
- Oncology
- Immunology
- Metabolism
Background:
- Bladder cancer (BC) progression is influenced by the tumor microenvironment (TME).
- Immune cells play critical roles in the BC TME, interacting with cancer cells.
- Metabolic competition within the TME impairs immune cell function.
Purpose of the Study:
- To review recent advances in immunometabolism.
- To relate these advances to bladder cancer progression.
- To highlight the role of metabolic reprogramming in BC and immune cells.
Main Methods:
- Literature review of recent studies in immunometabolism and bladder cancer.
- Analysis of molecular and metabolic factors influencing immune cell function in the TME.
- Correlation of immune cell metabolism with BC progression and treatment response.
Main Results:
- Metabolic competition in the TME leads to nutrient deprivation, acidosis, and hypoxia.
- Immune cell function is closely linked to their metabolic state.
- Metabolites in the TME regulate immune cell phenotype, function, and metabolism.
Conclusions:
- A deep understanding of metabolic reprogramming in BC cells and immune cells is crucial.
- Targeted therapies based on immunometabolism hold promise for future bladder cancer treatment.
- Further research into the TME's metabolic landscape can reveal novel therapeutic targets.
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