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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
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Herpes simplex virus-infected squamous cell carcinoma: a case report
Sarah H Brown1, Vanessa A R States2, Abaseen K Afghan3
1Vanderbilt University School of Medicine, 1161 21st Ave S #D3300, Nashville, TN, 37232, USA. sarah.h.brown.1@vanderbilt.edu.
BMC Infectious Diseases
|January 5, 2022
Summary
Herpes simplex virus (HSV)-1, a common virus, was found infecting malignant cells in a patient with buccal squamous cell carcinoma. This case highlights how cancer cells can be vulnerable to viral infections like HSV-1.
Area of Science:
- Oral Oncology
- Viral Oncology
- Immunocompromised Host Research
Background:
- Herpes simplex virus (HSV)-1 is a common virus causing superficial ulcerations.
- Immunocompromised individuals experience higher morbidity from HSV-1.
- HSV-1 is not considered oncogenic but may influence malignant progression.
Observation:
- A patient with a history of acute myelogenous leukemia and allogenic stem cell transplant presented with buccal squamous cell carcinoma.
- Histopathological examination of the carcinoma revealed HSV-1 infected malignant cells.
- The patient was treated with valacyclovir.
Findings:
- This case demonstrates the discovery of HSV-1 within malignant squamous cells of the buccal mucosa.
- The findings suggest cancer cells may be susceptible to secondary viral infections, including HSV-1.
- The patient's treatment with valacyclovir was successful.
Implications:
- This case underscores the potential for opportunistic viral infections in cancer patients, particularly those who are immunocompromised.
- Understanding viral-host interactions in cancer is crucial for managing immunocompromised patients.
- Further research may explore the role of viral infections in cancer progression and treatment.
