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Consideration Regarding the Analysis of Randomized Controlled Trials in the Era of Evidence-based Medicine
Pierre V Ennezat1, Zarrin Alavi2, Thierry H Le Jemtel3
1Department of Cardiology, Centre Hospitalier Universitaire Henri Mondor, Créteil, France.
Abstract:
Analysis of randomized controlled trials (RCTs) is the cornerstone of evidence-based medicine, therapeutic guidelines and ultimately daily practice. However, 2 issues contribute to cloud the analysis of RCTs. Industry-sponsored RCTs aim at capturing as large indications as possible and clinicians rely excessively on P value statistical significance for the evaluation of the findings. To be most valuable to practitioners, analysis of RCTs needs to provide absolute risk reduction, number of patients needed to treat, fragility index along with the estimation of lost to follow-up patients, and outcome postponement (gain in survival time). We analyzed few major cardiovascular RCTs and assessed the robustness of their findings. Our suggested analytic parameters may be further used in future systematic reviews and meta-analyses.
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