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The Association Between Cholecystectomy and Colorectal Cancer in the Female Gender
Fahad Aurif1, Harsimran Kaur2, Jeoffrey Patrick G Chio2
1General Surgery, California Institute of Behavioral Neuroscience and Psychology, Fairfield, USA.
Cureus
|January 5, 2022
Summary
Cholecystectomy (gallbladder removal) may increase colorectal cancer (CRC) risk in women. Altered bile acids after surgery could contribute to this association, particularly in the western female population.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Colorectal carcinoma (CRC) is a significant health concern with multifactorial causes.
- The potential link between cholecystectomy (CMY) and CRC, especially in women, warrants further investigation despite existing evidence suggesting an association.
Purpose of the Study:
- To investigate the association between CMY and CRC in the female population.
- To explore potential mechanisms underlying this observed association.
Main Methods:
- This review synthesizes existing evidence regarding CMY and CRC.
- Focuses on studies examining the female demographic and potential etiological factors.
Main Results:
- A positive association between CMY and CRC, particularly in the western female population, is noted.
- Altered bile acid composition post-CMY, leading to increased secondary bile acids in the intestines, is a proposed mechanism.
- Elevated fecal secondary bile acids in CMY patients are linked to increased cancer risk.
Conclusions:
- CMY may be a contributing factor to CRC development in women.
- Changes in bile acid metabolism following CMY represent a plausible pathway for this increased risk.
