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Cryptococcus gattii meningitis complicated by immune reconstitution inflammatory syndrome in an apparent

Chee Yik Chang1, Syarul Hafiz Mohd Shah1, Jia Yin Lio1

  • 1Infectious Disease Unit, Medical Department, Hospital Selayang, 68100, Batu Caves, Selangor, Malaysia.

Medical Mycology Case Reports
|January 5, 2022
PubMed

Insights

A rare Cryptococcus gattii meningitis case in Malaysia highlights potential risks even in immunocompetent individuals. This fungal infection presented with lung disease and immune reconstitution inflammatory syndrome.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Case Study

Background:

  • Cryptococcosis, a fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii, can lead to severe conditions like meningoencephalitis.
  • Cryptococcus gattii infections are infrequently documented in Malaysia, making local case reports significant.

Observation:

  • A case of Cryptococcus gattii meningitis with concurrent pulmonary cryptococcosis was observed.
  • The patient was apparently immunocompetent and had no history of international travel.

Findings:

  • The patient experienced immune reconstitution inflammatory syndrome (IRIS) as a complication.
  • This case underscores the possibility of severe C. gattii infections in seemingly healthy individuals.

Implications:

  • Highlights the importance of considering C. gattii even in immunocompetent hosts presenting with pulmonary and neurological symptoms.
  • Emphasizes the need for increased awareness and diagnostic vigilance for C. gattii infections in Malaysia.
  • Suggests potential for IRIS in cryptococcosis cases, even without a known immunocompromised state.
Keywords:
CryptococcosisCryptococcus gattiiImmune reconstitution inflammatory syndromePulmonary cryptococcosis

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