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Potential of Stem Cell-Based Therapy to Restore Function in Aging Systems: Are We There Yet?
Joshua M Hare1, Isabel Beerman2
1The Interdisciplinary Stem Cell Institute, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Summary
Cell-based therapies show promise for aging by restoring stem cell function. Supplementing stem cell capacity could improve healthspan and combat age-related frailty.
Area of Science:
- Geroscience
- Regenerative Medicine
- Cell Biology
Background:
- Extensive interest exists in geroscience for health and disease.
- Few basic science discoveries translate into clinical trials.
- Aging is associated with diminished endogenous regenerative capacity.
Purpose of the Study:
- To comment on cell-based therapies for aging.
- To highlight translational development in stem cell approaches.
- To discuss strategies for restoring aged stem cell niches.
Main Methods:
- Review of existing studies on cell-based therapies for aging.
- Focus on supplementing stem cell capacity in aged systems.
- Examination of approaches targeting single systems and overall frailty.
Main Results:
- Cell-based therapies offer a theoretical pathway for sustained improvement in aged systems.
- Translational development is underway for these approaches.
- Restoring aged stem cell niches is a key strategy.
Conclusions:
- Cell-based therapies represent an exciting geroscience approach.
- Supplementing stem cell capacity holds potential for improving healthspan.
- Targeting stem cell niches may combat aging frailty.
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