Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of the Vascular System01:20

Overview of the Vascular System

3.1K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.1K
Anastomoses01:19

Anastomoses

1.5K
In human anatomy, anastomosis refers to a connection or opening between two things, particularly between blood vessels or other tubular structures. The term is derived from the Greek term 'anastomosis,' which means 'outlet' or 'opening.' This natural network of connections plays a critical role in the survival and functionality of the human body.
Anastomoses can be formed at arterial, venous, and lymphatic vessels.
Arterial Anastomosis: These occur between arteries. They...
1.5K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.8K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.8K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.0K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.0K
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

45
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
45
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

44
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
44

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging the Diagnostic Gap in Neurofibromatosis Type 1: When to Consider NF1 cDNA Sequencing.

Pediatric dermatology·2026
Same author

Clinical Manifestations and Therapeutic Management of Reactive Infectious Mucocutaneous Eruption in Paediatric Patients: A Systematic Review.

Journal of cutaneous medicine and surgery·2026
Same author

Building consensus in pediatric dermatology research.

The Journal of investigative dermatology·2026
Same author

Simple preventative skin care regimen helps patients undergoing targeted CNS or PNS therapy: A multicenter single-arm trial.

Journal of the American Academy of Dermatology·2026
Same author

Clinical Characteristics and Management of Pediatric Hidradenitis Suppurativa: A Canadian Single-Centre Multidisciplinary Experience.

Journal of cutaneous medicine and surgery·2026
Same author

Efficacy and Safety of Moxifloxacin in Pediatric Hidradenitis Suppurativa: Results From the Canadian Multidisciplinary Registry of Pediatric HS.

Journal of cutaneous medicine and surgery·2026

Related Experiment Video

Updated: Oct 7, 2025

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.5K

Vascular anomalies: clinical perspectives.

Joao Guilherme Amaral1,2, Irene Lara-Corrales3,4

  • 1Division of Interventional Radiology, Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada. joao.amaral@sickkids.ca.

Pediatric Radiology
|January 5, 2022
PubMed
Summary

Vascular anomalies are classified as tumors or malformations. Clinical history and physical exams are crucial for diagnosing these conditions and guiding imaging choices.

Keywords:
Arteriovenous malformationCapillary malformationChildrenHemangiomaLymphatic malformationMagnetic resonance imagingVascular anomaliesVascular malformationsVascular tumorsVenous malformation

More Related Videos

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

9.9K
Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
08:27

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.

Published on: January 27, 2015

14.3K

Related Experiment Videos

Last Updated: Oct 7, 2025

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.5K
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

9.9K
Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
08:27

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.

Published on: January 27, 2015

14.3K

Area of Science:

  • Vascular Medicine
  • Diagnostic Imaging
  • Pathology

Background:

  • Vascular anomalies encompass a spectrum of conditions, broadly categorized into vascular tumors and vascular malformations based on cellular characteristics and behavior.
  • Accurate diagnosis is essential for appropriate management and treatment planning.

Purpose of the Study:

  • To outline the essential clinical history and physical examination findings required for diagnosing vascular anomalies.
  • To provide a review of the clinical presentations of common vascular tumors and malformations.

Main Methods:

  • Review of clinical history components relevant to vascular anomalies.
  • Physical examination techniques for evaluating vascular lesions.
  • Synthesis of clinical findings for common vascular tumors and malformations.

Main Results:

  • Key historical elements include onset, growth, symptoms, and associated medical conditions.
  • Physical examination should focus on lesion characteristics such as color, texture, compressibility, and pulsation.
  • Common vascular tumors (e.g., hemangiomas) and malformations (e.g., port-wine stains, venous malformations) have distinct clinical features.

Conclusions:

  • A thorough clinical assessment, including detailed history and physical examination, is fundamental for the initial diagnosis of vascular anomalies.
  • This clinical evaluation guides the selection of appropriate imaging modalities for further characterization.
  • Understanding the clinical findings of common vascular tumors and malformations aids in accurate diagnosis and management.