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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Formation of Supramolecular Nanostructures through in Situ Self-Assembly and Post-Assembly Modification of a

Yuki Shintani¹, Taku Ohtomi¹, Aya Shibata¹

¹Department of Life Science and Chemistry Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|January 5, 2022

Abstract:

Aqueous self-assembly of short peptides has attracted growing attention for the construction of supramolecular materials for various bioapplications. Herein, we describe how the thermolysin-assisted biocatalytic construction of a dipeptide hydrazide from an N-protected amino acid and an amino acid hydrazide leads to the formation of thermally stable supramolecular hydrogels. In addition, we demonstrate the post-assembly modification of the supramolecular architectures constructed in situ tethering hydrazide groups as a chemical handle by means of fluorescence imaging.

Keywords:

biocatalysis helical nanoribbons peptides post-assembly modifications self-assembly supramolecular hydrogels

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