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Related Experiment Videos

Aspergillus endophthalmitis.

R Sihota1, H C Agarwal, A K Grover

  • 1Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.

The British Journal of Ophthalmology
|August 1, 1987
PubMed
Summary
This summary is machine-generated.

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This report details the youngest infant diagnosed with endogenous Aspergillus endophthalmitis. Systemic amphotericin B achieved a complete cure in the unaffected eye, marking a first for Aspergillus ocular disease.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Endogenous fungal endophthalmitis is a rare but serious ocular infection.
  • Aspergillus species are an uncommon cause of endogenous endophthalmitis, particularly in neonates.

Observation:

  • A case of bilateral Aspergillus endophthalmitis in a 15-day-old infant is presented.
  • The infant had no identifiable systemic predisposing factors or source of infection.
  • Histopathological confirmation of Aspergillus etiology was obtained after enucleation of one atrophic eye.

Findings:

  • The infant represents the youngest documented case of endogenous Aspergillus endophthalmitis.
  • Systemic amphotericin B therapy was initiated for the remaining eye.
  • Excellent clinical results were observed in the fellow eye following treatment.

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Implications:

  • This case highlights the possibility of endogenous Aspergillus endophthalmitis in neonates without risk factors.
  • Complete clinical cure of Aspergillus ocular disease with systemic amphotericin B monotherapy is achievable.
  • This represents the first recorded instance of a complete cure in Aspergillus endophthalmitis using systemic therapy alone.