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Aspergillus endophthalmitis
R Sihota1, H C Agarwal, A K Grover
1Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
Abstract:
A case is reported of bilateral aspergillus endophthalmitis in an infant without any detectable systemic predisposition or focus of infection. The patient is the youngest recorded case of endogenous aspergillus endophthalmitis so far, with an onset of symptoms at the age of 15 days. After histopathological confirmation of the aetiology by enucleation of the atrophic eye, systemic amphotericin B therapy was instituted with excellent results in the fellow eye. This is the first recorded instance of a complete clinical cure in aspergillus ocular disease on systemic amphotericin B therapy alone.
Insights
This report details the youngest infant diagnosed with endogenous Aspergillus endophthalmitis. Systemic amphotericin B achieved a complete cure in the unaffected eye, marking a first for Aspergillus ocular disease.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Endogenous fungal endophthalmitis is a rare but serious ocular infection.
- Aspergillus species are an uncommon cause of endogenous endophthalmitis, particularly in neonates.
Observation:
- A case of bilateral Aspergillus endophthalmitis in a 15-day-old infant is presented.
- The infant had no identifiable systemic predisposing factors or source of infection.
- Histopathological confirmation of Aspergillus etiology was obtained after enucleation of one atrophic eye.
Findings:
- The infant represents the youngest documented case of endogenous Aspergillus endophthalmitis.
- Systemic amphotericin B therapy was initiated for the remaining eye.
- Excellent clinical results were observed in the fellow eye following treatment.
Implications:
- This case highlights the possibility of endogenous Aspergillus endophthalmitis in neonates without risk factors.
- Complete clinical cure of Aspergillus ocular disease with systemic amphotericin B monotherapy is achievable.
- This represents the first recorded instance of a complete cure in Aspergillus endophthalmitis using systemic therapy alone.