Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.7K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.7K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.1K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

433
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
433
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

3.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.5K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

1.5K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
1.5K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

1.7K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary Computed Tomography Angiography for the Diagnosis and Revascularization Guidance of Coronary Bifurcation Lesions: A Contemporary Review.

Journal of clinical medicine·2026
Same author

Angiopoietin-like Proteins 4 and 8 in Diabetic Complications: Associations with Neuropathy and Metabolic Parameters in Type 2 Diabetes.

Journal of clinical medicine·2026
Same author

Global inequities in biologic and targeted DMARD use in rheumatoid arthritis: cross-sectional data from the international COVAD-2 cohort.

Rheumatology international·2026
Same author

Meningoencephalitis Caused by Escherichia coli in an Adult With No Known Immunocompromising Conditions: A Case Report.

The American journal of case reports·2026
Same author

Corneal Confocal Microscopy as a Non-Invasive Marker of Small Fiber Neuropathy and Systemic Complications in Type 2 Diabetes: A Cross-Sectional Study.

Biomolecules·2026
Same author

Markers for the Severity of Multisystem Inflammatory Syndrome in Children: A Multivariate Analysis.

International journal of pediatrics·2026

Related Experiment Video

Updated: Oct 7, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.2K

Omentin-1 and diabetic foot.

Tsvetan Gatev1, Viktoriya Byalkova2, Ivan Poromanski3

  • 1Clinic of Endocrinology, University Hospital Alexandrovska, Department of Internal Medicine, Medical University-Sofia, Sofia, Bulgaria.

The International Journal of Lower Extremity Wounds
|January 5, 2022
PubMed
Summary

Omentin-1 levels are significantly higher in individuals with diabetic foot disease, suggesting this adipokine plays a role in the development of this diabetes complication.

Keywords:
AdipokinesOmentin-1diabetic foot disease

More Related Videos

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

4.6K
A Method for Islet Transplantation to the Omentum in Mouse
06:25

A Method for Islet Transplantation to the Omentum in Mouse

Published on: January 7, 2019

11.4K

Related Experiment Videos

Last Updated: Oct 7, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.2K
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

4.6K
A Method for Islet Transplantation to the Omentum in Mouse
06:25

A Method for Islet Transplantation to the Omentum in Mouse

Published on: January 7, 2019

11.4K

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Diabetology

Background:

  • Diabetic foot disease is a severe complication of diabetes mellitus, leading to significant disability and mortality.
  • The exact pathogenesis of diabetic foot disease is not fully understood, with limited research on the role of adipose tissue-derived hormones (adipokines).

Purpose of the Study:

  • To investigate the association between serum omentin-1 levels and the presence of diabetic foot disease in patients with type 2 diabetes.
  • To explore the potential role of omentin-1 in the pathogenesis of diabetic foot disease.

Main Methods:

  • A cross-sectional study involving 80 patients with type 2 diabetes, divided into groups with (n=36) and without (n=44) diabetic foot disease.
  • Standard anthropometric, clinical, and laboratory tests were performed, along with body composition analysis.
  • Serum omentin-1 levels were quantified using the Enzyme-Linked Immunosorbent Assay (ELISA) method.

Main Results:

  • Serum omentin-1 levels were significantly elevated in patients with diabetic foot disease (700.2±345.1 ng/ml) compared to those without (560.2±176.7 ng/ml).
  • This significant difference persisted after adjusting for potential confounding factors.
  • Omentin-1 demonstrated predictive value for the development of diabetic foot disease in regression analysis.

Conclusions:

  • Adipokines, specifically omentin-1, may be implicated in the pathogenesis of diabetic foot disease.
  • Elevated omentin-1 levels could serve as a biomarker for diabetic foot disease risk.