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Related Experiment Videos

Screening for complement deficiencies in unselected patients with meningitis.

J M Rasmussen1, I Brandslund, B Teisner

  • 1Department of Internal Medicine C, Odense University Hospital, Denmark.

Clinical and Experimental Immunology
|May 1, 1987
PubMed
Summary

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Complement deficiencies are not common in meningitis patients. However, elevated C3d levels in purulent meningitis indicate higher fatality risk, suggesting complement activation rather than deficiency.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Complement deficiency can increase susceptibility to infections.
  • Meningitis, particularly meningococcal disease, is a severe infection.
  • The role of complement system in meningitis pathogenesis requires further investigation.

Purpose of the Study:

  • To investigate the association between complement deficiency and meningitis.
  • To evaluate the correlation of complement activation markers with meningitis severity and outcomes.

Main Methods:

  • Screening 209 meningitis patients for complement deficiency using hemolytic activity and C3d levels.
  • Follow-up quantitative immunochemical measurements for individual complement components.
  • Comparing C3d levels between purulent, serous, and non-meningitis patients.

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Main Results:

  • No homozygous complement deficiencies were found.
  • One case of probable heterozygous C2-deficiency associated with pneumococcal meningitis.
  • Significantly increased plasma C3d levels in purulent meningitis and meningococcal disease patients.
  • Elevated C3d levels correlated with increased lethality in these patients.

Conclusions:

  • Complement deficiency is unlikely to be a common cause of sporadic purulent meningitis or meningococcal disease.
  • Elevated C3d levels suggest complement activation is associated with severe meningitis and poor prognosis.