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Related Experiment Video

Updated: Oct 7, 2025

Covalent Binding of Antibodies to Cellulose Paper Discs and Their Applications in Naked-eye Colorimetric Immunoassays
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Nanobody-Functionalized Cellulose for Capturing SARS-CoV-2.

Xin Sun1, Shaobo Yang1, Amal A Al-Dossary2

  • 1Department of Bioengineering, Northeastern Universitygrid.261112.7, Boston, Massachusetts, USA.

Applied and Environmental Microbiology
|January 5, 2022
PubMed
Summary
This summary is machine-generated.

We developed functionalized cellulose materials to capture SARS-CoV-2, the virus causing COVID-19. This cost-effective method enhances virus detection and filtration, aiding in diagnostics and reducing viral load.

Keywords:
COVID-19SARS-CoV-2cellulosecellulose binding domaincellulose binding proteinnanobody

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Area of Science:

  • Biotechnology
  • Materials Science
  • Virology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant global health threat.
  • Existing containment strategies like quarantines and vaccinations are insufficient, necessitating novel, cost-effective mitigation methods.
  • There is a need for efficient systems to capture and detect SARS-CoV-2 in various environments.

Purpose of the Study:

  • To develop a generic strategy for capturing SARS-CoV-2 using functionalized cellulose materials.
  • To create a bifunctional fusion protein for enhanced virus capture.
  • To integrate this system into a chromatography platform for continuous virus filtration.

Main Methods:

  • Engineered a bifunctional fusion protein combining a cellulose-binding domain and a nanobody targeting the SARS-CoV-2 receptor-binding domain.
  • Immobilized fusion proteins onto cellulose substrates for virus capture.
  • Developed a customizable chromatography system using porous cellulose for continuous fluid processing.

Main Results:

  • Functionalized cellulose substrates demonstrated enhanced capture efficiency for SARS-CoV-2 pseudoviruses (wild type and D614G variant).
  • The chromatography system effectively captured viruses from complex fluids in a continuous manner.
  • The developed method offers a cost-effective approach for virus capture and concentration.

Conclusions:

  • Functionalized cellulose materials provide a versatile platform for SARS-CoV-2 capture and filtration.
  • This technology can be applied to paper-based diagnostics, environmental monitoring, and reducing viral loads.
  • The antigen-specific capture method complements existing viral detection and filtration technologies.