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Related Experiment Videos

Gastrointestinal side effects with erythromycin preparations.

B L Carter1, J C Woodhead, K J Cole

  • 1College of Pharmacy, University of Iowa, Iowa City 52242.

Drug Intelligence & Clinical Pharmacy
|September 1, 1987
PubMed
Summary

Erythromycin commonly causes gastrointestinal (GI) side effects. Patients experienced more GI issues with the enteric-coated tablet formulation compared to other erythromycin salts, leading to higher discontinuation rates.

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Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Gastroenterology

Background:

  • Erythromycin is a widely prescribed antibiotic.
  • Gastrointestinal (GI) side effects are common adverse events associated with erythromycin therapy.
  • Different salt forms of erythromycin may influence its tolerability and side effect profile.

Purpose of the Study:

  • To determine the incidence and severity of gastrointestinal (GI) side effects in patients using erythromycin.
  • To compare the GI side effect profiles of different erythromycin salt formulations.

Main Methods:

  • The study involved patients prescribed erythromycin.
  • Data collection focused on reported gastrointestinal (GI) side effects and treatment discontinuations.
  • Incidence rates of GI side effects were compared across different erythromycin salt forms: enteric-coated, stearate, and ethylsuccinate.

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Main Results:

  • A high incidence of GI side effects was observed in patients taking erythromycin.
  • The enteric-coated erythromycin tablet formulation showed a higher complaint rate (70.8%) for GI side effects compared to stearate (51.4%) and ethylsuccinate (48.9%) salts.
  • The enteric-coated formulation was linked to a greater number of individual adverse reactions and a higher rate of discontinuation due to GI effects.

Conclusions:

  • Erythromycin is associated with a significant incidence of gastrointestinal (GI) side effects.
  • The enteric-coated tablet formulation of erythromycin appears to have a higher incidence of GI side effects and is more likely to lead to treatment discontinuation compared to other salt forms.