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The 2022 Nucleic Acids Research database issue and the online molecular biology database collection
Daniel J Rigden1, Xosé M Fernández2
1Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK.
Nucleic Acids Research
|January 6, 2022
Summary
The 2022 Nucleic Acids Research Database Issue features 185 papers, introducing 87 new databases and updating 85 existing ones. Key resources cover COVID-19, protein structures, genomics, and pharmacology.
Area of Science:
- Bioinformatics and Computational Biology
- Genomics and Proteomics
- Molecular Biology and Genetics
Background:
- The 2022 Nucleic Acids Research (NAR) Database Issue presents a comprehensive overview of the latest advancements in biological databases.
- This year's issue includes 185 papers, with 87 new databases and 85 updates to existing resources, alongside 13 updates from databases published elsewhere.
Discussion:
- The issue highlights significant new resources, including seven COVID-19 and SARS-CoV-2 specific databases like SCoV2-MD.
- Major updates are provided for key nucleic acid databases (MODOMICS, JASPAR, miRTarBase) and protein databases (AlphaFold Protein Structure Database, Human Proteoform Atlas, GproteinDb).
- Coverage extends to disordered proteins (DisProt, FuzDB, ELM), metabolism and signaling (Reactome, ConsensusPathDB, HMDB, CAZy), microbial/viral genomes (LPSN, TYGS, GTDB), and genomics (Ensembl, UCSC Genome Browser).
Key Insights:
- The AlphaFold Protein Structure Database and SCoV2-MD are highlighted as Breakthrough Articles.
- The NAR online Molecular Biology Database Collection now totals 1645 entries, with 89 new resources and 317 updated entries in the latest release.
- The issue emphasizes the growing importance of specialized databases for specific research areas, including plant genomics and pharmacology.
Outlook:
- The continuous expansion and updating of biological databases are crucial for advancing research in molecular biology, genomics, and proteomics.
- Future database development will likely focus on integrating diverse data types and improving accessibility for researchers worldwide.
- The accessibility of the entire Database Issue online facilitates the adoption and utilization of these vital research tools.
