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Two new compounds from edible mushroom Sarcomyxa edulis
Lan Yao1,2, Jian-Hua Lv1, Mei-Chen Pan1
1Internationally Cooperative Research Center of China for New Germplasm Breeding of Edible Mushroom, Ministry of Science and Technology, Jilin Agricultural University, Changchun, PR China.
Abstract:
Chemical investigation of the edible mushroom Sarcomyxa edulis led to the isolation of one new highly degraded sterol (1), and one new β-carboline alkaloid (2), along with nine known compounds (3-11) for the first time from this mushroom. The structures of new compounds were elucidated using HR-ESI-MS data and NMR spectroscopy. In addition, anti-inflammatory activity of new compounds was evaluated against lipopolysaccharide-induced NO production in RAW 264.7 macrophages. Compound 2 exhibited a good anti-inflammatory activity with IC50 value of 9.88 ± 0.48 μM, and compound 1 exhibited a weak inhibitory effect with IC50 value of 71.36 ± 5.11 μM.
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Fungal Phylum Basidiomycota
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