Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monocytoid B-cell lymphoma.

C S Ng1, J K Chan

  • 1Department of Morbid Anatomy, University of Hong Kong, Prince of Wales Hospital.

Human Pathology
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

This study describes a rare malignant lymphoma, likely originating from monocytoid B cells. Immunohistochemistry confirmed B-cell markers, differentiating it from T-cell or monocytic cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decline in Cancer Diagnoses during the 'Zero COVID' Policy in Hong Kong: Indirect Spillover Impact of the COVID-19 Pandemic.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Malaysian consensus statement on FDG PET-CT reporting format for lymphoma.

The Medical journal of Malaysia·2021
Same author

A challenging road to diagnosing transthyretin cardiac amyloidosis and using technetium-99m pyrophosphate bone scintigraphy in nuclear cardiology - A case report.

The Medical journal of Malaysia·2021
Same author

Glomus Tumor of Sella Turcica With Synaptophysin Expression Mimicking Pituitary Adenoma.

International journal of surgical pathology·2020
Same author

A web-based educational intervention module to improve knowledge and attitudes towards thalassaemia prevention in Malaysian young adults.

The Medical journal of Malaysia·2019
Same author

Gastrointestinal: Solitary fibrous tumor from lesser omentum: An elderly from Malaysia with an unusual huge painful intra-abdominal mass.

Journal of gastroenterology and hepatology·2017
Same journal

TRPS1 and GATA3 Expression in BRG1/SMARCA4-deficient Malignant Neoplasms.

Human pathology·2026
Same journal

Clinicopathologic and Molecular Characteristics of Acral Melanomas Harboring RARA Fusions.

Human pathology·2026
Same journal

Clinical Impact of Second Opinion Consultation in Bladder Biopsies and Transurethral Resection of Bladder Tumors.

Human pathology·2026
Same journal

Prognostic relevance and molecular correlates of Claudin-1 expression in pancreatic neuroendocrine tumors.

Human pathology·2026
Same journal

Mixed Phenotype Acute Leukemia: Lineage Assignment, Immunophenotypic Classification and Genetic Insights.

Human pathology·2026
Same journal

Chronic myelomonocytic leukemia revisited: A comprehensive review with emphasis on the oligomonocytic subtype.

Human pathology·2026
See all related articles

Area of Science:

  • Hematology
  • Oncology
  • Immunopathology

Background:

  • Monocytoid B cells are a distinct B-cell subset with unique immunophenotypic characteristics.
  • Malignant lymphomas can arise from various B-cell lineages, presenting diagnostic challenges.

Observation:

  • A case of malignant lymphoma with morphological features suggestive of monocytoid B-cell origin was investigated.
  • Lymphoma cells exhibited medium-sized, oval to indented nuclei and pale cytoplasm.

Findings:

  • Immunohistochemical analysis demonstrated positivity for pan-B cell markers (B1, B4, BA2) and IgM lambda.
  • Crucially, the cells were positive for HLA-DR (12) but negative for T-cell and monocytic markers.
  • These findings support the classification of the lymphoma as the neoplastic counterpart of monocytoid B cells.

Related Experiment Videos

Implications:

  • This case expands the understanding of B-cell lymphomas and their potential origins.
  • Accurate immunophenotyping is critical for diagnosing and classifying rare lymphoid malignancies.
  • Further research into monocytoid B-cell lymphomas may reveal specific therapeutic targets.