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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
56
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
103
Layers of the Heart Wall01:15

Layers of the Heart Wall

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The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
3.7K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

40
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

43
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Updated: Oct 7, 2025

Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics
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Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics

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Leishmaniasis and Heart.

Juan Ma Farina1, Carlos E García-Martínez2, Clara Saldarriaga3

  • 1Division of Cardiology, Clínica Olivos, Buenos Aires, Argentina.

Archivos De Cardiologia De Mexico
|January 6, 2022
PubMed
Summary
This summary is machine-generated.

Leishmaniasis, a neglected tropical disease, can cause severe cardiac issues, yet cardiac involvement remains understudied. This review explores cardiac complications and treatment cardiotoxicity to improve patient outcomes.

Keywords:
Cardiac diseaseEnfermedad cardiovascularEnfermedades tropicales desatendidasLeishmaniasisNeglected diseases

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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Area of Science:

  • Tropical medicine
  • Cardiology
  • Infectious diseases

Background:

  • Leishmaniasis is a neglected tropical disease impacting impoverished populations, with visceral leishmaniasis being its most severe form.
  • Cardiac involvement in leishmaniasis is rare but potentially lethal, with limited research and screening recommendations.
  • Cardiotoxicity from leishmaniasis treatments necessitates understanding drug side effects for patient safety.

Purpose of the Study:

  • To review existing literature on cardiac implications of leishmaniasis and its treatment.
  • To identify barriers in diagnosing and treating cardiac manifestations of leishmaniasis.
  • To propose strategies for overcoming diagnostic and therapeutic challenges.

Main Methods:

  • Comprehensive literature review of leishmaniasis and cardiac involvement.
  • Analysis of case reports and clinical studies on cardiotoxicity.
  • Synthesis of information within the NET-Heart Project framework.

Main Results:

  • Cardiac manifestations of leishmaniasis are under-recognized and under-studied.
  • Cardiotoxicity is a significant concern associated with leishmaniasis drug treatments.
  • Lack of clear diagnostic and screening guidelines hinders timely intervention.

Conclusions:

  • Further research is crucial to understand and manage cardiac complications of leishmaniasis.
  • Developing standardized screening protocols and treatment guidelines for cardiac involvement is essential.
  • Addressing barriers to diagnosis and treatment can improve patient prognosis and reduce mortality.