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Spondylodiscitis due to Salmonella Typhi: a series of four cases

Kavitha Saravu1,2, Shyamasunder N Bhat3, Nitin Gupta1,2

  • 1Department of Infectious Diseases, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Oxford Medical Case Reports
|January 6, 2022
PubMed

Insights

Salmonella Typhi rarely causes bone and joint issues, but can lead to spondylodiscitis, especially in at-risk individuals. Early microbiological diagnosis is crucial for effective treatment of this rare infection.

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Microbiology

Background:

  • Salmonella Typhi is a rare cause of focal bone and joint infections.
  • Such complications are classically associated with underlying risk factors like hemoglobinopathies.

Observation:

  • This report details four cases of spondylodiscitis attributed to Salmonella Typhi.
  • The patients presented with spinal infection, a seldom-seen manifestation of typhoid fever.

Findings:

  • All four patients with Salmonella Typhi-induced spondylodiscitis achieved successful treatment outcomes.
  • Treatment involved a variable duration of ceftriaxone followed by cotrimoxazole.

Implications:

  • Highlights the importance of microbiological diagnosis in suspected bone and joint infections.
  • Underscores the potential for rare Salmonella Typhi infections in endemic regions, even without typical risk factors.

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