Early Experience With Tenecteplase at a Comprehensive Stroke Center

Area of Science:

• Neurology
• Cardiovascular Medicine
• Pharmacology

Background:

• Acute ischemic stroke requires timely reperfusion therapy.
• Tenecteplase is an alternative thrombolytic agent with potential benefits.
• Existing clinical guidelines inform thrombolytic treatment decisions.

Purpose of the Study:

• To review clinical trials and guidelines for tenecteplase in acute stroke.
• To describe the development and implementation of a clinical pathway for tenecteplase use.
• To facilitate adoption of this pathway in other stroke centers.

Main Methods:

• Review of existing literature on tenecteplase in stroke.
• Development of a clinical decision algorithm.
• Operationalization of a clinical pathway for tenecteplase administration.
• Case presentation of successful implementation.

Main Results:

• Tenecteplase has been successfully administered to patients at the center.
• Implementation of the clinical pathway demonstrated feasibility.
• A case illustrates the effective use of IV tenecteplase.

Conclusions:

• A detailed protocol enables other centers to establish similar pathways.
• Tenecteplase can be effectively integrated into acute ischemic stroke treatment.
• This approach supports optimized thrombolytic therapy for stroke patients.