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Updated: Oct 7, 2025

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Early Experience With Tenecteplase at a Comprehensive Stroke Center
Spozhmy Panezai1, Ilya Dubinsky1, Sindhu Sahito1
1HMH JFK University Medical Center (SP, SS, NG, LS, SM, JK), Neuroscience Institute, Edison, NJ; and Emergency Department (ID), HMH JFKUMC, Edison, NJ.
Purpose Of Review:
Tenecteplase has been studied and recommended as an alternative thrombolytic agent in patients with acute stroke. A brief review of clinical trials and guidelines pertinent to our clinical decision algorithm is described. This is followed by operational steps that were made to create and implement a clinical pathway based on available evidence in which tenecteplase is used in select patients with stroke at our comprehensive stroke center.
Recent Findings:
A number of patients have been treated at our center with IV tenecteplase. A case is presented to illustrate the successful implementation of this new process.
Summary:
Development of our protocol is discussed in detail to enable other centers to create their own clinical pathways for thrombolytic treatment of acute ischemic stroke using tenecteplase.
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