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Acromegaly and the Colon: Scoping Beyond the Pituitary
Gautami S Patel1, Idan Grossmann2, Kevin Rodriguez3
1Internal Medicine, Pramukhswami Medical College, Karamsad, IND.
Cureus
|January 6, 2022
Summary
Acromegaly, a disorder of growth hormone (GH) excess, is linked to increased colorectal neoplasia risk. Early screening for colorectal cancer is crucial for managing this endocrine disorder.
Area of Science:
- Endocrinology
- Oncology
- Gastroenterology
Background:
- Acromegaly results from excess growth hormone (GH), often from pituitary tumors.
- While treated patients have average life expectancy, acromegaly causes multi-systemic complications.
- Malignancy, particularly colorectal cancer, is an emerging concern in acromegaly.
Purpose of the Study:
- To review the association between acromegaly and colorectal neoplasia.
- To explore potential pathogenic mechanisms linking the two conditions.
- To summarize clinical presentations and screening recommendations.
Main Methods:
- Literature review compiling studies on acromegaly and colorectal neoplasia.
- Analysis of pathogenic pathways.
- Summary of clinical findings and guidelines.
Main Results:
- Evidence suggests a link between acromegaly and increased prevalence of colorectal neoplasia.
- Potential mechanisms involve GH/IGF-1 signaling pathways.
- Clinical presentations and screening guidelines are discussed.
Conclusions:
- Acromegaly patients face an elevated risk of colorectal neoplasia.
- Understanding the pathogenic link is vital for patient management.
- Routine colorectal cancer screening is recommended for individuals with acromegaly.
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