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TRIM29 in Cutaneous Squamous Cell Carcinoma.

Che-Yuan Hsu1, Teruki Yanagi1, Hideyuki Ujiie1

  • 1Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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|January 6, 2022
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Summary

Tripartite motif 29 (TRIM29) protein, encoded by the ATDC gene, is crucial in cell processes and cancer. Its silencing via DNA methylation promotes skin cancer cell migration.

Keywords:
ATDCFAM83HTRIM29cell migrationkeratinsquamous cell carcinoma

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Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Tripartite motif (TRIM) proteins are vital regulators of cellular functions including immunity and cell death.
  • TRIM29, an ATDC gene product, functions as an E3 ubiquitin ligase and is implicated in DNA damage, carcinogenesis, and radiosensitivity.
  • TRIM29 interacts with keratins and FAM83H, influencing keratin distribution.

Purpose of the Study:

  • To review the role of TRIM family proteins in malignant tumors.
  • To specifically elucidate the function of TRIM29 in cutaneous squamous cell carcinoma (SCC).

Main Methods:

  • Literature review of TRIM family proteins and TRIM29.
  • Analysis of TRIM29's interactions with keratins and FAM83H.
  • Examination of TRIM29's role in DNA methylation and keratinocyte migration in cutaneous SCC.

Main Results:

  • TRIM29's involvement in DNA binding, dimerization, and signaling pathways related to DNA damage.
  • TRIM29's role in suppressing radiosensitivity and its implication in carcinogenesis.
  • Silencing of TRIM29 expression by DNA methylation in cutaneous SCC leads to loss of TRIM29 function and enhanced keratinocyte migration.

Conclusions:

  • TRIM29 plays a significant role in malignant tumor development.
  • Epigenetic silencing of TRIM29 by DNA methylation is a key mechanism promoting cutaneous SCC progression.
  • Understanding TRIM29's function offers potential therapeutic targets for skin cancer.