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Unmet needs in inflammatory bowel disease.
Joana Revés1, Ryan C Ungaro2, Joana Torres1,3
1Division of Gastroenterology, Surgical Department, Hospital Beatriz Ângelo, Loures, Portugal.
Current Research in Pharmacology and Drug Discovery
|January 6, 2022
Summary
Despite advancements, inflammatory bowel diseases (IBD) management requires further research. This review addresses unanswered questions in Crohn's Disease and Ulcerative Colitis care by examining chronic disease management stages.
Area of Science:
- Gastroenterology and Hepatology
- Internal Medicine
Background:
- Inflammatory bowel diseases (IBD), including Crohn's Disease and Ulcerative Colitis, present ongoing challenges despite diagnostic and therapeutic progress.
- Patients continue to experience debilitating symptoms and serious complications, highlighting unmet needs in IBD care.
Purpose of the Study:
- To identify and address critical unanswered questions in the management of IBD.
- To propose research priorities by aligning current IBD challenges with a chronic disease management framework.
Main Methods:
- The review analyzes IBD management through the lens of five chronic disease stages: pre-treatment evaluation, induction therapy, maintenance therapy, monitoring/re-establishment of control, and disease cessation.
- It synthesizes existing knowledge and identifies gaps within each stage.
Main Results:
- Key questions and unmet needs are highlighted across all stages of IBD management.
- The chronic disease paradigm provides a structured approach to understanding and prioritizing research efforts in IBD.
Conclusions:
- A systematic approach, viewing IBD as a chronic condition with distinct management phases, is crucial for advancing patient care.
- Further research is needed to address specific questions within each management stage to improve outcomes for Crohn's Disease and Ulcerative Colitis patients.
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