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Updated: Oct 7, 2025

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

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Is autosomal dominant polycystic kidney disease an early sweet disease?

Angélique Dachy1,2,3, Jean-Paul Decuypere1, Rudi Vennekens4

  • 1PKD Research Group, GPURE, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Pediatric Nephrology (Berlin, Germany)
|January 6, 2022
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) may be worsened by obesity. This review explores glucose metabolism

Area of Science:

  • Nephrology
  • Metabolic Disorders
  • Pediatric Research

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) has early childhood onset.
  • Overweight and obesity are linked to faster ADPKD progression in adults.
  • Metabolic reprogramming and glucose metabolism defects are implicated in ADPKD.

Purpose of the Study:

  • To review the role of glucose metabolism in ADPKD pathophysiology.
  • To highlight the risks of overweight and obesity in ADPKD, particularly in children.
  • To discuss potential metabolic therapeutic targets for ADPKD.

Main Methods:

  • Literature review of studies on ADPKD, glucose metabolism, and obesity.
  • Analysis of current and emerging metabolic interventions for ADPKD.
  • Examination of pediatric obesity trends and their implications for ADPKD.

Main Results:

  • Accumulating evidence supports early nephron-protective strategies and lifestyle changes for ADPKD.
  • Defective glucose metabolism pathways are potential therapeutic targets in ADPKD.
  • Childhood obesity crisis presents risks for pediatric ADPKD patients' cardiovascular and renal health.

Conclusions:

  • Understanding glucose metabolism is crucial for managing ADPKD.
  • Overweight and obesity pose significant risks to ADPKD prognosis, especially long-term cardiovascular and renal outcomes.
  • Further research is needed on metabolic interventions for pediatric ADPKD.

Keywords:
Autosomal dominant polycystic kidney diseaseChildrenGlucoseInsulinObesityOverweight

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