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Updated: Oct 7, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
CA-125 variation in acute heart failure: a single-centre analysis.
Patrícia Lourenço1,2,3,4, Filipe M Cunha5, Catarina Elias1
1Internal Medicine Department, Centro Hospitalar e Universitário São João, Porto, Portugal.
A decrease in carbohydrate antigen 125 (CA-125) levels after acute heart failure (HF) hospitalization predicts improved survival. This prognostic value is significant for patients with a hospital stay exceeding 10 days.
Area of Science:
- Cardiology
- Biomarkers
- Heart Failure Research
Background:
- Carbohydrate antigen 125 (CA-125) decrease is linked to better survival in chronic heart failure.
- The prognostic significance of CA-125 variation in acute heart failure (HF) remains unclear.
Purpose of the Study:
- To investigate the association between CA-125 decrease and prognosis in patients hospitalized with acute heart failure.
- To determine the predictive value of CA-125 levels and their changes on mortality in acute HF.
Main Methods:
- Studied 363 acute HF patients with high comorbidity burden.
- Utilized Cox-regression analysis to assess CA-125 levels and decrease against 1-year all-cause mortality.
- Stratified analysis by length of hospital stay (LOS).
Main Results:
- CA-125 levels increased significantly from admission to discharge (56.0 to 74.0 U/mL).
- Both admission and discharge CA-125 levels predicted mortality.
- A decrease in CA-125 was associated with a 68% reduction in 1-year death risk, but only in patients with LOS > 10 days.
Conclusions:
- An early re-evaluation (>10 days) of CA-125 levels post-acute HF hospitalization may aid patient management.
- CA-125 dynamics, particularly a decrease after prolonged hospitalization, offer prognostic insights in acute heart failure.
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