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Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial
Fernanda L Mendonça1, Fabiana Giuseppina Di Campli Regnault1, Camilla C L Di Leone1
1Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
JMIR Research Protocols
|January 6, 2022
Summary
This study compares three treatments for molar incisor hypomineralization (MIH) sensitivity in children. Results will inform treatment protocols for MIH-related dental sensitivity.
Area of Science:
- Pediatric Dentistry
- Dental Materials Science
- Clinical Trials
Background:
- Molar incisor hypomineralization (MIH) causes significant tooth sensitivity in children, impacting their quality of life.
- Current desensitizing agents like sodium fluoride varnish show promise but require more long-term clinical evidence for MIH treatment recommendations.
Purpose of the Study:
- To compare the effectiveness of three interventions for managing hypersensitivity in children with MIH.
- To evaluate sodium fluoride varnish, titanium tetrafluoride varnish, and a PRG Barrier Coat resin for treating MIH-related tooth sensitivity.
Main Methods:
- A randomized clinical trial involving 60 children (aged 6-10) with sensitive first permanent molars due to MIH.
- Participants were assigned to receive sodium fluoride varnish, 4% titanium tetrafluoride varnish, or PRG Barrier Coat resin.
- Sensitivity was assessed using validated scales (Wong-Baker FACES, Schiff Cold Air, FLACC) at multiple time points up to 6 months post-treatment.
Main Results:
- Participant recruitment was completed in November 2019.
- The study is currently underway, with initial results anticipated for publication in 2022.
Conclusions:
- This trial will provide crucial data on the long-term efficacy of novel agents for MIH sensitivity.
- Findings may lead to the development of standardized treatment protocols for managing sensitivity in teeth affected by MIH.
